博昌復健 ― 增生療法與運動傷害治療中心 Bo Chung Prolotherapy and Rehabilitation Clinic

葡萄糖是自然界分布最廣且最為重要的一種單糖。葡萄糖是一種多羥基醛。水溶液旋光向右，故亦稱「右旋糖」。葡萄糖在生物學領域具有重要地位，是活細胞的能量來源和新陳代謝中間產物。葡萄糖增生注射療(Dextrose  Prolotherapy)藉由多種機制啟動修復，包含葡萄糖直接的反應、滲透壓(osmotic)誘發反應與發炎生長效應(inflammatory growth effect)。葡萄糖增生注射治的濃度如果在10%以上，會造成細胞處於滲透壓梯度變化下。這樣的滲透壓變化會讓注射區域的細胞失去水分，進而開啟生長因子流入(influx)細胞與患部修復連鎖反應(wound-healing cascade)。
 

葡萄糖水是非常理想的增生劑，原因是(一)葡糖糖是屬於水溶性、(二)葡萄糖是人體正常血液中的化學物質，因此安全性佳，即便打在身體多個區域或是使用較大劑量，都相對安全。葡萄糖增生注射治的最終結果，可使新生的膠原蛋白(collagen)積累在受傷韌帶與肌腱上。人體正常的細胞中，葡萄糖含量僅有 0.1%。增加葡萄糖的濃度可以促進細胞蛋白質的合成、DNA的合成、細胞體積(cell volume)的增加與細胞增生 (cell proliferation)。

正常人類細胞處於0.5%的葡萄糖濃度環境下，便會誘發細胞增生，並刺激多種生長因子的產，例如血小板生長因子(platelet-derived growth factor, PDGF)、轉化生長因子β (transforming growth factor-beta, TGF-β)、表皮細胞生長因子(epidermal growth factor, EGF), 鹼性纖維母細胞生長因子(basic fibroblast growth factor,  bFGF), 類胰島素生長因子(insulin-like growth factor, IGF-1), 結締組織生長因子(connective tissue growth factor, CTGF)。這些生長因子與肌腱、韌帶、軟組織的修復、健康狀態與生長有關。

許多研究指出，葡萄糖注射到動物與人類的組織中，會刺激韌帶增厚、肌腱肥大(tendon hypertrophy)、增加細胞外間質成分(extracellular matrix)、纖維母細胞增(fibroblastic proliferation)、修復關節軟骨缺損(articular cartilage defects)。葡萄糖增生注射被證實，在不同的葡萄糖濃度下，可以誘發修復反應，保護收受傷的軟骨組織，且產生發炎性(inflammatory)與非發炎性(noninflammatoryru)的生化效應。

By Ross H, et al. Evidence-Based Use of Dextrose Prolotherapy for Musculoskeletal Pain: A Scientific Literature Review. Journal of Prolotherapy. 2011;3(4):765-789.

http://www.journalofprolotherapy.com/pdfs/issue_12/issue_12_03_evidence_based_prolo.pdf

增生療法門診時間
 

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博昌增生療法與復健科診所關心您  台北市萬華區萬大路221號

picture from http://dentistryandmedicine.blogspot.tw/2011/10/regeneration-healing-repair.html

參考文獻

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